Pair Name	Juglone, Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	PTGS2	hsa5743
	Down-regulation	Expression	TNF	hsa7124
In Vivo Model	Adult male Balb/c mice were used in this study.
Result	IND and JUG reduce the inflammatory activity and induce apoptotic cell death, while JUG effectively prevents IND induced gastric ulceration. These findings establish that a combination of IND + JUG may serve as a promising treatment regimen for colon cancer.

Pair Name	Juglone, Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BBC3	hsa27113
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CYCS	hsa54205
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	PTGS2	hsa5743
	Down-regulation	Expression	TNF	hsa7124
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	A combination of both was shown to be more effective, suggesting that juglone may be considered for therapeutic intervention of colon cancer.