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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Gossypol, Zoledronic acid
Phytochemical Name Gossypol (PubChem CID: 3503 )
Anticancer drug Name Zoledronic acid (PubChem CID: 68740 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 875
Ref_1
Pair Name Gossypol, Zoledronic acid
Disease Info [ICD-11: 2C82] Prostate cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAD hsa572
Up-regulation Expression BAX hsa581
Down-regulation Expression BIRC2 hsa329
Down-regulation Expression BIRC3 hsa330
Down-regulation Expression BIRC5 hsa332
Down-regulation Expression BIRC7 hsa79444
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression CDKN1B hsa1027
Down-regulation Expression CLSPN hsa63967
Up-regulation Expression FAS hsa355
Down-regulation Expression HMOX1 hsa3162
Down-regulation Expression HSPD1 hsa3329
Down-regulation Expression PON2 hsa5445
Down-regulation Expression TP53 hsa7157
In Vitro Model DU145 Prostate carcinoma Homo sapiens (Human) CVCL_0105
Result GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins.
03. Reference
No. Title Href
1 Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. Cell Biol Int. 2009 Nov;33(11):1165-72. doi: 10.1016/j.cellbi.2009.08.006. Click
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