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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Baculoviral IAP repeat-containing protein 7
UniProt ID BIRC7_HUMAN
Gene Name BIRC7
Gene ID 79444
Synonyms
BIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Sequence
MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLR
PLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQD
KVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPW
EEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVE
AQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
Pathway Map MAP LINK
KEGG ID hsa79444
TTD ID T42247
Pfam PF00097; PF00653; PF01412; PF10217; PF13445; PF13639; PF13920; PF13923; PF14447; PF14634; PF15227; PF15616; PF21362
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 875
Pair Name Gossypol, Zoledronic acid
Phytochemical Gossypol
Drug Zoledronic acid
Disease Info [ICD-11: 2C82.0] Prostate cancer Investigative
Regulate Info Down-regulation Baculoviral IAP repeat-containing protein 7 Expression
Result GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins.
03. Reference
No. Title Href
1 Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. Cell Biol Int. 2009 Nov;33(11):1165-72. doi: 10.1016/j.cellbi.2009.08.006. Click
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