Pair Name	Gamma-Tocotrienol, SU11274
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	CDH1	hsa999
	Up-regulation	Expression	CTNNB1	hsa1499
	Up-regulation	Expression	KRT18	hsa3875
	Up-regulation	Expression	KRT8	hsa3856
	Down-regulation	Phosphorylation	NFKB1	hsa4790
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Phosphorylation	PTEN	hsa5728
	Down-regulation	Phosphorylation	STAT1	hsa6772
	Down-regulation	Phosphorylation	STAT5	hsa6776
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	+SA	The highly malignant +SA cell line was derived from an adenocarcinoma developed spontaneously in a BALB/c female mouse	Mus musculus (Mouse)	N.A.
Result	Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity.