| Pair Name | Chrysin, Fluorouracil | ||
| Phytochemical Name | Chrysin (PubChem CID: 5281607 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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3D
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| Structure of Anticancer Drug |
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| Pair Name | Chrysin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Up-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | CDK6 | hsa1021 | |
| Down-regulation | Expression | CDK1 | hsa983 | |
| Down-regulation | Expression | CCNB1 | hsa891 | |
| In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
| Result | Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells. Oncol Lett. 2021 Jan;21(1):24. doi: 10.3892/ol.2020.12285. | Click |
