Pair Name	Cepharanthine, Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Mitochondrial fission and apoptosis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	CFL1	hsa1072
	Up-regulation	Expression	CYCS	hsa54205
	Down-regulation	Phosphorylation	DNM1L	hsa10059
	Down-regulation	Phosphorylation	LIMK1	hsa3984
	Up-regulation	Expression	LINC01554	KEGG ID N.A.
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	MFF	hsa56947
	Down-regulation	Expression	MFN1	hsa55669
	Down-regulation	Expression	MFN2	hsa9927
	Down-regulation	Expression	OPA1	hsa4976
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	PINK1	hsa65018
	Up-regulation	Expression	PRKN	hsa5071
	Up-regulation	Expression	SQSTM1	hsa8878
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	BT-549	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_1092
In Vivo Model	MDA-MB-231 cells were suspended in a 1:1 ratio in DMEM medium with a Matrigel basement membrane matrix . Cells (4×10⁷) were inoculated in the right legs of mice.
Result	Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis