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caffeic acid phenethyl ester, caffeic acid phenyl ester, CAPE compound, CAPEEE, phenethyl caffeate, phenyl caffeate

No.	Title	Href
1	Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line. J Exp Pharmacol. 2022 Jul 23;14:243-253. doi: 10.2147/JEP.S365159.	`Click`
2	Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells. Biochem Pharmacol. 2022 Mar;197:114900. doi: 10.1016/j.bcp.2021.114900.	`Click`
3	An in vitro and in vivo investigation of the cytotoxic effects of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester and bortezomib in multiple myeloma cells. Turk J Med Sci. 2015;45(1):38-46. doi: 10.3906/sag-1401-127.	`Click`
4	Caffeic Acid Phenethyl Ester (CAPE) Synergistically Enhances Paclitaxel Activity in Ovarian Cancer Cells. Molecules. 2023 Aug 1;28(15):5813. doi: 10.3390/molecules28155813.	`Click`
5	Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway. Kaohsiung J Med Sci. 2023 Jun;39(6):605-615. doi: 10.1002/kjm2.12675.	`Click`

No.

Title

Href

Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line. J Exp Pharmacol. 2022 Jul 23;14:243-253. doi: 10.2147/JEP.S365159.

Click

Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells. Biochem Pharmacol. 2022 Mar;197:114900. doi: 10.1016/j.bcp.2021.114900.

Click

An in vitro and in vivo investigation of the cytotoxic effects of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester and bortezomib in multiple myeloma cells. Turk J Med Sci. 2015;45(1):38-46. doi: 10.3906/sag-1401-127.

Click

Caffeic Acid Phenethyl Ester (CAPE) Synergistically Enhances Paclitaxel Activity in Ovarian Cancer Cells. Molecules. 2023 Aug 1;28(15):5813. doi: 10.3390/molecules28155813.

Click

Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway. Kaohsiung J Med Sci. 2023 Jun;39(6):605-615. doi: 10.1002/kjm2.12675.

Click

Name	Caffeic acid phenethyl ester
PubChem CID	5281787
Molecular Weight	284.31g/mol
Synonyms	caffeic acid phenethyl ester, caffeic acid phenyl ester, CAPE compound, CAPEEE, phenethyl caffeate, phenyl caffeate
Formula	C₁₇H₁₆O₄
SMILES	C1=CC=C(C=C1)CCOC(=O)C=CC2=CC(=C(C=C2)O)O
InChI	1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
InChIKey	SWUARLUWKZWEBQ-VQHVLOKHSA-N
CAS Number	115610-29-2
ChEMBL ID	CHEMBL319244
ChEBI ID	CHEBI:8062
KEGG ID	C10484
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	FengJiao
Use Part	Bee glue
Habitat	Shandong, Beijing, Henan, Jiangsu, Hangzhou, Xinjiang
Flavor	Pungent; Bitter
Meridian Tropism	Spleen; Stomach
Species	>Kingdom: Metazoa 　-->Phylum: Arthropoda 　　-->Class: Insecta 　　　-->Order: Hymenoptera 　　　　-->Family: Apidae 　　　　　-->Genus: Apis 　　　　　　-->Species: Apis mellifera

Pair Name	Caffeic acid phenethyl ester, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
Gene Regulation	Up-regulation	Expression	BAX	hsa581
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	This study demonstrated the cytotoxicity of CAPE potential to induce apoptosis of breast cancer MCF-7 cell line single and cytotoxic-cytostatic combination with 5-FU. Therefore, further studies to develop CAPE and its derivatives will be required to discover new candidates for breast cancer agents.

Pair Name	Caffeic acid phenethyl ester, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Gene Regulation	Down-regulation	Expression	USP8	hsa9101
	Up-regulation	Expression	PSMD9	hsa5715
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	TOV-112D	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_3612
In Vitro Model	IGROV-1/Pt1	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_EQ62
In Vivo Model	Exponentially growing cells (1×10⁷/mouse) were inoculated i.p. or s.c. into the right flank on day 0 forming experimental groups of 7 animals.
Result	This study reveals the therapeutic potential of CAPE in cisplatin-resistant ovarian tumors as well as in tumors expressing USP8.

Pair Name	Caffeic acid phenethyl ester, Bortezomib
Partner Name	Bortezomib
Disease Info	[ICD-11: 2A83.1]	Multiple myeloma		Investigative
Gene Regulation	Down-regulation	Expression	IL6	hsa3569
Gene Regulation	Down-regulation	Activity	NFKB1	hsa4790
In Vitro Model	ARH-77	Plasma cell myeloma	Homo sapiens (Human)	CVCL_1072
In Vivo Model	Female BALB/c mice (5–6 weeks old) were use in this study.
Result	We think that our study, which is the first to demonstrate the in vitro and in vivo effectiveness of the.combined use of CAPE and bortezomib, will be a pioneer for future human applications of CAPE in MM.

Pair Name	Caffeic acid phenethyl ester, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Inhibition-->Cell migration
In Vitro Model	OV7	Ovarian carcinoma	Homo sapiens (Human)	CVCL_2675
Result	The simultaneous administration of PTX and CAPE enhanced the anti-migration activity of the chemotherapeutic used in this study.

Pair Name	Caffeic acid phenethyl ester, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Lipid metabolism
Gene Regulation	Down-regulation	Expression	SREBF1	hsa6720
	Down-regulation	Expression	ACACA	hsa31
	Down-regulation	Expression	FASN	hsa2194
	Down-regulation	Expression	SCD	hsa6319
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	MTOR	hsa2475
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our results suggest that CAPE treatment reversed DOX resistance in breast cancer cells, at least in part by inhibiting Akt/mTOR/SREBP1 pathway-mediated lipid metabolism, indicating that CAPE may be an effective substance to assist in the treatment of breast cancer.