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  1. General Info
  2. Effects Info
  3. Reference
Molecular Details
01. General Information
Name Stearoyl-CoA desaturase
UniProt ID SCD_HUMAN
Gene Name SCD
Gene ID 6319
Synonyms
SCD, FADS5, MSTP008, SCD1, SCDOS, hSCD1
Sequence
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
Pathway Map MAP LINK
T.C. Number 1.B.38.4.2; 3.A.1.134.3; 3.A.25.1.1; 3.A.6.1.1; 3.A.6.3.1; 8.A.3.2.2; 8.A.3.2.3; 8.A.9.1.3
KEGG ID hsa6319
Pfam PF21581
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 243
Pair Name (20S)-Protopanaxatriol, EGFR-TKI
Phytochemical (20S)-Protopanaxatriol
Drug EGFR-TKI
Disease Info [ICD-11: 2C25.Z] Lung cancer Investigative
Regulate Info Down-regulation Stearoyl-CoA desaturase Expression
Result Our findings uncover a link between lipid metabolic reprogramming and EGFR-TKI resistance, confirmed that combination target both EGFR and abnormal lipid metabolism maybe a promising therapy for EGFR-TKI resistance and highlighting the possibility of monitoring lipid accumulation in tumors for predicting drug resistance.
Combination Pair ID: 780
Pair Name Caffeic acid phenethyl ester, Doxorubicin
Phytochemical Caffeic acid phenethyl ester
Drug Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Regulate Info Down-regulation Stearoyl-CoA desaturase Expression
Result Our results suggest that CAPE treatment reversed DOX resistance in breast cancer cells, at least in part by inhibiting Akt/mTOR/SREBP1 pathway-mediated lipid metabolism, indicating that CAPE may be an effective substance to assist in the treatment of breast cancer.
03. Reference
No. Title Href
1 Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. J Exp Clin Cancer Res. 2019 Mar 15;38(1):129. doi: 10.1186/s13046-019-1120-4. Click
2 Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway. Kaohsiung J Med Sci. 2023 Jun;39(6):605-615. doi: 10.1002/kjm2.12675. Click
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