TOP
Nav Bar
  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name All-trans retinoic acid, Midostaurin
Phytochemical Name All-trans retinoic acid (PubChem CID: 444795 )
Anticancer drug Name Midostaurin (PubChem CID: 9829523 )
Structure of
Phytochemical
2D-img
Download
2D MOL 3D MOL
Structure of
Anticancer Drug
2D-img
Download
2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
Hide/Show
Enhancing Drug Efficacy
Hide/Show
Combination Pair ID: 515
Pair Name All-trans retinoic acid, Midostaurin
Disease Info [ICD-11: 2A60.Z] Acute myeloid leukemia Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BRAF hsa673
Down-regulation Expression CASP3 hsa836
Down-regulation Expression CASP7 hsa840
Up-regulation Expression CEBPB hsa1051
Up-regulation Expression CEBPE hsa1053
Up-regulation Expression FGR hsa2268
Up-regulation Expression LYN KEGG ID N.A.
Up-regulation Phosphorylation MAP2K7 hsa5609
Up-regulation Phosphorylation MAPK1 hsa5594
Up-regulation Phosphorylation RAF1 hsa5894
Up-regulation Expression SPI1 hsa6688
In Vitro Model HL-60 Adult acute myeloid leukemia Homo sapiens (Human) CVCL_0002
U-937 Adult acute monocytic leukemia Homo sapiens (Human) CVCL_0007
HL-60Res Resistant Adult acute myeloid leukemia Homo sapiens (Human) N.A.
In Vivo Model Mice were injected subcutaneously with 5×10⁶ cells.
Result Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3
03. Reference
No. Title Href
1 Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3. BMC Cancer. 2022 Jul 9;22(1):749. doi: 10.1186/s12885-022-09828-2. Click
It has been 48340 visits since 2024.08
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang
TOP