| Name | Tyrosine-protein kinase Fgr | ||
| UniProt ID | FGR_HUMAN | ||
| Gene Name | FGR | ||
| Gene ID | 2268 | ||
| Synonyms |
FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr
|
||
| Sequence |
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT |
||
| Pathway Map | MAP LINK | ||
| T.C. Number | 3.A.1.105.15 | ||
| KEGG ID | hsa2268 | ||
| TTD ID | T49925 | ||
| Pfam | PF00017; PF00018; PF00069; PF03109; PF07653; PF07714; PF12330; PF14604; PF17902; PF17978 | ||
| Pair Name | All-trans retinoic acid, Midostaurin | |||
| Phytochemical | All-trans-retinoic acid | |||
| Drug | Midostaurin | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Regulate Info | Up-regulation | Tyrosine-protein kinase Fgr | Expression | |
| Result | Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3 | |||
