| Name | Transcription factor PU.1 | ||
| UniProt ID | SPI1_HUMAN | ||
| Gene Name | SPI1 | ||
| Gene ID | 6688 | ||
| Synonyms |
SPI1, AGM10, OF, PU.1, SFPI1, SPI-1, SPI-A
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| Sequence |
MLQACKMEGFPLVPPPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVHS
EFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCLQ YPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDLL RSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGE VKKVKKKLTYQFSGEVLGRGGLAERRHPPH |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.C.36.3.2 | ||
| KEGG ID | hsa6688 | ||
| Pfam | PF00178; PF20041 | ||
| Pair Name | All-trans retinoic acid, Midostaurin | |||
| Phytochemical | All-trans-retinoic acid | |||
| Drug | Midostaurin | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Regulate Info | Up-regulation | Transcription factor PU.1 | Expression | |
| Result | Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3 | |||
