InterPAD - DETAILS

Midostaurin, PKC412, 120685-11-2, Cgp 41251, PKC-412, 4'-N-Benzoylstaurosporine, Benzoylstaurosporine, RYDAPT, CGP-41251, PKC 412, N-Benzoylstaurosporine, UNII-ID912S5VON, ID912S5VON, NVP-PKC412, CHEBI:63452, NSC-656576, CHEMBL608533, CGP 41231, NSC 656576, N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamide, 4'-N-benzoyl staurosporine, MIDOSTAURIN (MART.), MIDOSTAURIN [MART.], Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-, N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide, CGP41251, N-benzoyl-staurosporine, Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methyl-, N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide, Midostaurin [INN], Cgp 41 251, Midostaurin [USAN:INN], midostaurina, midostaurine, midostaurinum, PKC412;CGP 41251, N-((5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo(b,h)cyclonona(1,2,3,4-jkl)cyclopenta(e)-as-indacen-7-yl)-N-methylbenzamide, Rydapt (TN), Midostaurin(PKC412), MIDOSTAURIN [MI], Staurosporine, N-Benzoyl, MIDOSTAURIN [JAN], MIDOSTAURIN [USAN], MIDOSTAURIN [WHO-DD], Midostaurin (JAN/USAN/INN), GTPL5702, SCHEMBL8295379, L01XE39, MIDOSTAURIN [ORANGE BOOK], BMGQWWVMWDBQGC-IIFHNQTCSA-N, GLXC-02502, HMS3229K17, EX-A1741, BDBM50326053, MFCD00871372, NSC800791, s8064, AKOS024457372, CCG-101288, CS-3331, DB06595, NSC-800791, NCGC00241102-01, NCGC00241102-02, NCGC00241102-05, NCGC00484987-03, AC-31929, HY-10230, NS00073185, PA-9829523, C71714, D05029, J-004379, Q6842945, BRD-K13646352-001-01-2, N-Benzoylstaurosporine , PKC412 , CGP41231 , CGP 41251, N-((9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-4-yl]-N-methylbenzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-4-yl]-N-methyl-benzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

Name	Midostaurin
PubChem CID	9829523
Molecular Weight	570.6g/mol
Synonyms	Midostaurin, PKC412, 120685-11-2, Cgp 41251, PKC-412, 4'-N-Benzoylstaurosporine, Benzoylstaurosporine, RYDAPT, CGP-41251, PKC 412, N-Benzoylstaurosporine, UNII-ID912S5VON, ID912S5VON, NVP-PKC412, CHEBI:63452, NSC-656576, CHEMBL608533, CGP 41231, NSC 656576, N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamide, 4'-N-benzoyl staurosporine, MIDOSTAURIN (MART.), MIDOSTAURIN [MART.], Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-, N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide, CGP41251, N-benzoyl-staurosporine, Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methyl-, N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide, Midostaurin [INN], Cgp 41 251, Midostaurin [USAN:INN], midostaurina, midostaurine, midostaurinum, PKC412;CGP 41251, N-((5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo(b,h)cyclonona(1,2,3,4-jkl)cyclopenta(e)-as-indacen-7-yl)-N-methylbenzamide, Rydapt (TN), Midostaurin(PKC412), MIDOSTAURIN [MI], Staurosporine, N-Benzoyl, MIDOSTAURIN [JAN], MIDOSTAURIN [USAN], MIDOSTAURIN [WHO-DD], Midostaurin (JAN/USAN/INN), GTPL5702, SCHEMBL8295379, L01XE39, MIDOSTAURIN [ORANGE BOOK], BMGQWWVMWDBQGC-IIFHNQTCSA-N, GLXC-02502, HMS3229K17, EX-A1741, BDBM50326053, MFCD00871372, NSC800791, s8064, AKOS024457372, CCG-101288, CS-3331, DB06595, NSC-800791, NCGC00241102-01, NCGC00241102-02, NCGC00241102-05, NCGC00484987-03, AC-31929, HY-10230, NS00073185, PA-9829523, C71714, D05029, J-004379, Q6842945, BRD-K13646352-001-01-2, N-Benzoylstaurosporine , PKC412 , CGP41231 , CGP 41251, N-((9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-N-methylbenzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-4-yl]-N-methylbenzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-4-yl]-N-methyl-benzamide, N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide
Drug Type	Small molecule
Formula	C₃₅H₃₀N₄O₄
SMILES	CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
InChI	1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
InChIKey	BMGQWWVMWDBQGC-IIFHNQTCSA-N
CAS Number	120685-11-2
ChEMBL ID	CHEMBL608533
ChEBI ID	CHEBI:63452
TTD ID	D07NVU
Drug Bank ID	DB06595
KEGG ID	D05029
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	All-trans retinoic acid, Midostaurin
Partner Name	All-trans-retinoic acid
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BRAF	hsa673
	Down-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	CEBPB	hsa1051
	Up-regulation	Expression	CEBPE	hsa1053
	Up-regulation	Expression	FGR	hsa2268
	Up-regulation	Expression	LYN	KEGG ID N.A.
	Up-regulation	Phosphorylation	MAP2K7	hsa5609
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	RAF1	hsa5894
	Up-regulation	Expression	SPI1	hsa6688
In Vitro Model	HL-60	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_0002
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
	HL-60Res	Resistant Adult acute myeloid leukemia	Homo sapiens (Human)	N.A.
In Vivo Model	Mice were injected subcutaneously with 5×10⁶ cells.
Result	Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3