| Pair Name | Tangeretin, Fluorouracil | ||
| Phytochemical Name | Tangeretin (PubChem CID: 68077 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Tangeretin, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BID | hsa637 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Down-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Phosphorylation | RB1 | hsa5925 | |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| Down-regulation | Expression | TXN | KEGG ID N.A. | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| HCT 15 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0292 | |
| KM12-C | Colon carcinoma | Homo sapiens (Human) | CVCL_9547 | |
| Result | To our knowledge gained from literature, this study is the first to describe synergistic activity of TAN and 5-FU against colorectal cancer cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell. Food Chem Toxicol. 2020 Sep;143:111529. doi: 10.1016/j.fct.2020.111529. | Click |
