| Name | Rhizoma Paridis saponins | ||
| PubChem CID | / | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZhongLou | ||
| Use Part | Rhizome | ||
| Habitat | YunNan, GuiZhou, GuangDong, GuangXi, HuBei | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliaceae
-->Family: Liliaceae
-->Genus: Paris
-->Species: Paris polyphylla
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| Pair Name | Rhizoma Paridis saponins, Sorafenib | |||
| Partner Name | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Glycolysis | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | CPT1A | hsa1374 | |
| Down-regulation | Expression | CPT1A | hsa1374 | |
| Up-regulation | Activity | DUOX2 | hsa50506 | |
| Down-regulation | Expression | FASN | hsa2194 | |
| Down-regulation | Expression | HIF1A | hsa3091 | |
| Down-regulation | Expression | LDHA | hsa3939 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Down-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| Up-regulation | Activity | SDHB | hsa6390 | |
| Down-regulation | Expression | SLC2A1 | hsa6513 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vivo Model | 5×10⁶ of H22 tumor cells were subcutaneously subaxillary inoculated in 24 mice. | |||
| Result | All of that provided possibility to overcome the intolerance of sorafenib by drug compatibility through protection against mitochondria damage, inhibition of anaerobic glycolysis and suppression of lipid synthesis based on PI3K/Akt/mTOR pathway. | |||
