| Name | Succinate dehydrogenase [ubiquinone] iron-sulfur | ||
| UniProt ID | SDHB_HUMAN | ||
| Gene Name | SDHB | ||
| Gene ID | 6390 | ||
| Synonyms |
SDHB, CWS2, IP, MC2DN4, PGL4, PPGL4, SDH, SDH1, SDH2, SDHIP
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| Sequence |
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 3.D.10.1.7 | ||
| KEGG ID | hsa6390 | ||
| Pfam | PF00111; PF13085; PF13183; PF13187; PF13237; PF13534; PF13746 | ||
| Pair Name | Rhizoma Paridis saponins, Sorafenib | |||
| Phytochemical | Rhizoma Paridis saponins | |||
| Drug | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Up-regulation | Succinate dehydrogenase [ubiquinone] iron-sulfur | Activity | |
| Result | All of that provided possibility to overcome the intolerance of sorafenib by drug compatibility through protection against mitochondria damage, inhibition of anaerobic glycolysis and suppression of lipid synthesis based on PI3K/Akt/mTOR pathway. | |||
