2,4,3',5'-tetrahydroxystilbene, oxyresveratrol, puag-haad
| Name | Oxyresveratrol | ||
| PubChem CID | 5281717 | ||
| Molecular Weight | 244.24g/mol | ||
| Synonyms |
2,4,3',5'-tetrahydroxystilbene, oxyresveratrol, puag-haad |
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| Formula | C₁₄H₁₂O₄ | ||
| SMILES | C1=CC(=C(C=C1O)O)C=CC2=CC(=CC(=C2)O)O | ||
| InChI | 1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+ | ||
| InChIKey | PDHAOJSHSJQANO-OWOJBTEDSA-N | ||
| CAS Number | 29700-22-9 | ||
| ChEMBL ID | CHEMBL43065 | ||
| ChEBI ID | CHEBI:7870 | ||
| Herb ID | HBIN038513 | ||
| KEGG ID | C10273 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | BaQia | ||
| Use Part | Rhizome | ||
| Habitat | JiangSu, FuJian, HuNan, SiChuan | ||
| Flavor | Sweet, Mildly bitter, Astringent | ||
| Meridian Tropism | Liver, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Smilacaceae
-->Genus: Smilax
-->Species: Smilax china
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| Chineses Pinyin | YiZhi | ||
| Use Part | Fruit | ||
| Habitat | HaiNan, GuangDong | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Alpinia
-->Species: Alpinia oxyphylla
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| Chineses Pinyin | SangBaiPi | ||
| Use Part | Root Bark | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Moraceae
-->Genus: Morus
-->Species: Morus alba
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| Chineses Pinyin | SangZhi | ||
| Use Part | Young Twig | ||
| Habitat | JiangSu, ZheJiang | ||
| Flavor | Mildly bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Moraceae
-->Genus: Morus
-->Species: Morus alba
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| Chineses Pinyin | DaDaHeMianBaoGuo | ||
| Use Part | Fruit | ||
| Habitat | YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Moraceae
-->Genus: Artocarpus
-->Species: Artocarpus lacucha
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| Chineses Pinyin | GouJi | ||
| Use Part | Root | ||
| Habitat | GuangDong, ZheJiang, JiangXi, FuJian | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Moraceae
-->Genus: Maclura
-->Species: Maclura cochinchinensis
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| Chineses Pinyin | MaoYeLiLu | ||
| Use Part | Root, Rhizome | ||
| Habitat | SiChuan, HuBei, HuNan, JiangXi, ZheJiang, TaiWan, YunNan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliales
-->Family: Melanthiaceae
-->Genus: Veratrum
-->Species: Veratrum grandiflorum
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| Chineses Pinyin | SangCheng | ||
| Use Part | Leaf, Root, Fruit | ||
| Habitat | HeBei | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Moraceae
-->Genus: Maclura
-->Species: Maclura pomifera
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| Chineses Pinyin | XiaoYeMaiMaTeng | ||
| Use Part | Root; leaf; Rattan | ||
| Habitat | FuJian, GuangXi, GuangDong, YunNan | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gnetales
-->Family: Gnetaceae
-->Genus: Gnetum
-->Species: Gnetum parvifolium
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| Pair Name | Oxyresveratrol, Dacarbazine | |||
| Partner Name | Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in S phase | |||
| Gene Regulation | Down-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | NOTCH2 | hsa4853 | |
| Down-regulation | Expression | NOTCH3 | hsa4854 | |
| In Vitro Model | WM266-4 | Melanoma | Homo sapiens (Human) | CVCL_2765 |
| Result | This combination treatment may serve as a novel therapeutic strategy for treating malignant melanoma. | |||
