Pair Name	Oleuropein, Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	MMP7	hsa4316
	Down-regulation	Expression	NGF	hsa4803
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	Our results showed for the first time that the anti-tumor activity of oleuropein against HCC could be attributed to influencing the pro-NGF/NGF balance via affecting MMP-7 activity without affecting the gene expression of NGF. Concurrent treatment with both oleuropein and cisplatin could lead to more effective chemotherapeutic combination against HCC.

Pair Name	Oleuropein, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	GDE1	hsa51573
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	A2780/CP70	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0135
Result	These data revealed that oleuropein regulated the expression of the above-mentioned miRNAs in ovarian cancer cells, which potentially resulted in apoptosis induction, cell proliferation inhibition, and cisplatin resistance decline in ovarian cancer cells. To confirm the results of this study, it is suggested that similar experiments be performed in animal models of ovarian cancer.