| Pair Name | Mangiferin, Doxorubicin | ||
| Phytochemical Name | Mangiferin (PubChem CID: 5281647 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Mangiferin, Doxorubicin | |||
| Disease Info | [ICD-11: 2A83] | Multiple myeloma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in sub-G1 phase | |||
| Gene Regulation | Down-regulation | Expression | BCL-xL | hsa598 |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Up-regulation | Expression | PMAIP1 | hsa5366 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | IM-9 | Healthy | Homo sapiens (Human) | CVCL_1305 |
| RPMI-8226 | Plasma cell myeloma | Homo sapiens (Human) | CVCL_0014 | |
| Result | Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway. Int J Oncol. 2016 Jun;48(6):2704-12. doi: 10.3892/ijo.2016.3470. | Click |
