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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Lupeol, Fluorouracil
Phytochemical Name Lupeol (PubChem CID: 259846 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 1027
Ref_1
Pair Name Lupeol, Fluorouracil
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Inhibition-->Cell metastasis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CDH1 hsa999
Down-regulation Phosphorylation EPHA2 hsa1969
Down-regulation Phosphorylation MET hsa4233
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression SNAI1 hsa6615
Down-regulation Expression SNAI2 hsa6591
Down-regulation Expression TWIST1 hsa7291
Down-regulation Expression VIM hsa7431
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
4T1 Malignant neoplasms of the mouse mammary gland Mus musculus (Mouse) CVCL_0125
In Vivo Model 4T1 cells (1×10⁶) were injected into the abdominal mammary fat pads of BALB/c mice.
Result These data lay the foundation for the clinical validation of this combination therapy for TNBC patients.
03. Reference
No. Title Href
1 Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer. iScience. 2023 Nov 4;26(12):108395. doi: 10.1016/j.isci.2023.108395. Click
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