| Pair Name | Gambogic Acid, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Gambogic Acid (PubChem CID: 9852185 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gambogic Acid, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | BID | hsa637 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Down-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| Result | These findings may open a new window in the treatment of breast cancer using TRAIL in combination with GA. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food Chem Toxicol. 2018 Sep;119:334-341. doi: 10.1016/j.fct.2018.02.037. | Click |
