| Pair Name | Fangchinoline, Everolimus | ||
| Phytochemical Name | Fangchinoline (PubChem CID: 73481 ) | ||
| Anticancer drug Name | Everolimus (PubChem CID: 6442177 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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| Pair Name | Fangchinoline, Everolimus | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | MAP1LC3B | hsa81631 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | EIF4EBP1 | hsa1978 | |
| Up-regulation | Expression | NOTCH1 | hsa4851 | |
| Up-regulation | Expression | NOTCH3 | hsa4854 | |
| Up-regulation | Expression | HES1 | hsa3280 | |
| Up-regulation | Expression | MYC | hsa4609 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| NCI-H358 | Minimally invasive lung adenocarcinoma | Homo sapiens (Human) | CVCL_1559 | |
| HCC827 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_2063 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1511 | |
| Result | Firstly link CHOP to Notch 3/c-MYC axis-dependent apoptosis and provide the Notch 3/c-MYC/CHOP activation as a promising strategy for mTOR-targeted combination therapy in lung cancer treatment. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Activation of notch 3/c-MYC/CHOP axis regulates apoptosis and promotes sensitivity of lung cancer cells to mTOR inhibitor everolimus. Biochem Pharmacol. 2020 May;175:113921. doi: 10.1016/j.bcp.2020.113921. | Click |
