| Name | Ribosyldihydronicotinamide dehydrogenase | ||
| UniProt ID | NQO2_HUMAN | ||
| Gene Name | NQO2 | ||
| Gene ID | 4835 | ||
| Synonyms |
NQO2, DHQV, DIA6, NMOR2, QR2
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| Sequence |
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa4835 | ||
| TTD ID | T75498 | ||
| Pfam | PF02525; PF03358 | ||
| Pair Name | Curcumol, TNF-related apoptosis inducing ligand | |||
| Phytochemical | Curcumol | |||
| Drug | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Regulate Info | Down-regulation | Ribosyldihydronicotinamide dehydrogenase | Expression | |
| Result | This study characterizes the functional role of NQO2 in TRAIL resistance and the sensitizing function of curcumol by directly targeting NQO2, highlighting the potential of using curcumol as an NQO2 inhibitor for clinical treatment of TRAIL-resistant cancers. | |||
