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1-O-galloyl-3,6-(R)-hexahydroxydiphenol-beta-D-glucose, corilagin

No.	Title	Href
1	Corilagin sensitizes epithelial ovarian cancer to chemotherapy by inhibiting Snail‑glycolysis pathways. Oncol Rep. 2017 Oct;38(4):2464-2470. doi: 10.3892/or.2017.5886.	`Click`
2	Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Phytother Res. 2014 May;28(5):781-3. doi: 10.1002/ptr.5049.	`Click`
3	Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78. Sci Rep. 2023 Dec 19;13(1):22661. doi: 10.1038/s41598-023-49604-1.	`Click`

No.

Title

Href

Corilagin sensitizes epithelial ovarian cancer to chemotherapy by inhibiting Snail‑glycolysis pathways. Oncol Rep. 2017 Oct;38(4):2464-2470. doi: 10.3892/or.2017.5886.

Click

Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Phytother Res. 2014 May;28(5):781-3. doi: 10.1002/ptr.5049.

Click

Corilagin enhances the anti-tumor activity of 5-FU by downregulating the expression of GRP 78. Sci Rep. 2023 Dec 19;13(1):22661. doi: 10.1038/s41598-023-49604-1.

Click

Name	Corilagin
PubChem CID	73568
Molecular Weight	634.5g/mol
Synonyms	1-O-galloyl-3,6-(R)-hexahydroxydiphenol-beta-D-glucose, corilagin
Formula	C₂₇H₂₂O₁₈
SMILES	C1C2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)O)OC(=O)C4=CC(=C(C(=C4C5=C(C(=C(C=C5C(=O)O1)O)O)O)O)O)O)O
InChI	1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1
InChIKey	TUSDEZXZIZRFGC-XIGLUPEJSA-N
CAS Number	2088321-44-0
ChEMBL ID	CHEMBL449392
ChEBI ID	CHEBI:3884
Herb ID	HBIN021473
KEGG ID	C10219
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	BiMaZi
Use Part	Seed
Habitat	China
Flavor	Sweet, Pungent
Meridian Tropism	Large intestine, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Ricinus 　　　　　　-->Species: Ricinus communis

Chineses Pinyin	JingDaJi
Use Part	Root
Habitat	JiangSu, SiChuan, JiangXi, GuangXi
Flavor	Bitter
Meridian Tropism	Lung, Spleen, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Euphorbiaceae 　　　　　-->Genus: Euphorbia 　　　　　　-->Species: Euphorbia pekinensis

Chineses Pinyin	LaoGuanCao
Use Part	Aerial Parts
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, JiangSu, ZheJiang, AnHui, FuJian, JiangXi, ShanDong, ShangHai, HeNan, HuBei, HuNan, Shaanxi, GanSu, SiChuan
Flavor	Pungent, Bitter
Meridian Tropism	Liver, Kidney, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Geraniales 　　　　-->Family: Geraniaceae 　　　　　-->Genus: Erodium 　　　　　　-->Species: Erodium stephanianum

Chineses Pinyin	LongYanRou
Use Part	Aril
Habitat	GuangDong, FuJian, TaiWan, GuangXi
Flavor	Sweet
Meridian Tropism	Heart, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Sapindaceae 　　　　　-->Genus: Dimocarpus 　　　　　　-->Species: Dimocarpus longan

Chineses Pinyin	HeZiYe
Use Part	Leaf
Habitat	YunNan, SiChuan, GuiZhou, YunNan, XiZang, ChongQing, GuangDong, GuangXi
Flavor	Bitter
Meridian Tropism	Lung, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Myrtales 　　　　-->Family: Combretaceae 　　　　　-->Genus: Terminalia 　　　　　　-->Species: Terminalia chebula

Chineses Pinyin	MaoGuoQi
Use Part	Bark
Habitat	ZheJiang, AnHui, JiangXi, HuBei
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Vitales 　　　　-->Family: Vitaceae 　　　　　-->Genus: Acer 　　　　　　-->Species: Acer nikoense

Chineses Pinyin	YeXiaZhu
Use Part	Whole herb with root
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Magnoliopsida 　　　-->Order: Malpighiales 　　　　-->Family: Phyllanthaceae 　　　　　-->Genus: Emblica 　　　　　　-->Species: Emblica urinaria

Pair Name	Corilagin, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
In Vitro Model	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
Result	We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.

Pair Name	Corilagin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in S phase
Gene Regulation	Down-regulation	Expression	CDK2	hsa1017
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	HSPA5	hsa3309
In Vitro Model	HCT 8	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_2478
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
Result	Our results indicate that Corilagin acts as a potentiator of 5-fluorouracil and may have therapeutic potential for patients with CRC.

Pair Name	Corilagin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Inhibition-->Glycolysis
Gene Regulation	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Expression	STAT3	hsa6774
In Vitro Model	KOV3.ip1	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0C84
	HEY	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_0297
	HO-8910	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6868
Result	Our observations indicate that corilagin sensitized epithelial ovarian cancer cells to paclitaxel and carboplatin treatment by primarily inhibiting Snail-glycolysis pathways. Corilagin is a herbal medicine with low toxic effects to normal cells, particularly hepatoprotective, and may be an ideal complimentary medicine when combined with highly toxic chemotherapeutic agents.