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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Capsaicin, 3,3'-diindolylmethane
Phytochemical Name Capsaicin (PubChem CID: 1548943 )
Anticancer drug Name 3,3'-diindolylmethane (PubChem CID: 3071 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 831
Ref_1
Pair Name Capsaicin, 3,3'-diindolylmethane
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAK1 hsa578
Up-regulation Expression BAX hsa581
Up-regulation Expression BBC3 hsa27113
Up-regulation Expression BID hsa637
Up-regulation Expression CDH13 hsa1012
Down-regulation Expression CDK4 hsa1019
Down-regulation Expression CDK6 hsa1021
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression FAS hsa355
Up-regulation Expression IFI27 hsa3429
Up-regulation Expression TP53 hsa7157
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
LoVo Colon adenocarcinoma Homo sapiens (Human) CVCL_0399
HT-29 Colon adenocarcinoma Homo sapiens (Human) CVCL_0320
Caco-2 Colon adenocarcinoma Homo sapiens (Human) CVCL_0025
SW480 Colon adenocarcinoma Homo sapiens (Human) CVCL_0546
Result The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-κB, p53, and target genes associated with apoptosis.
03. Reference
No. Title Href
1 Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer. J Agric Food Chem. 2015 May 6;63(17):4297-304. doi: 10.1021/jf506098s. Click
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