InterPAD - DETAILS

3,3'-Diindolylmethane, 1968-05-4, diindolylmethane, di(1H-indol-3-yl)methane, 3,3'-Methylenebis-1H-indole, 3,3'-Methylenediindole, DIM, 1H-Indole, 3,3'-methylenebis-, 3-(1H-indol-3-ylmethyl)-1H-indole, ARUNDINE, 3,3-Diindolylmethane, 3,3'-Di-indolylmethane, Plant Indole, 3,3'-methylenebis(1H-indole), 33'-Diindolylmethane, Di(3-indolyl)methane, 3,3'-methanediylbis(1H-indole), MFCD00195766, SSZ9HQT61Z, bis-1H-indol-3-ylmethane, CHEBI:50182, 3,3,-diindolylmethane, 3,3 inverted exclamation marka-Diindolylmethane, 3-Diindolyl methane, 3,3'-Diindolymethane, Diidolylmethane, Infemin, CCRIS 5806, 33diindolylmethyle, Di-3-indolylmethane, NSC708486, 3-3-diindolylmethane, Bis (3-indolyl)methane, Spectrum2_001711, Spectrum3_001989, Spectrum5_001955, UNII-SSZ9HQT61Z, DIM;Arundine;HB 236, CBiol_001839, Oprea1_472633, Oprea1_740951, BSPBio_001290, BSPBio_003589, CBDivE_010856, KBioGR_000010, KBioSS_000010, MLS006011847, SCHEMBL325162, SPECTRUM1505331, SPBio_001722, 3-3'-DIINDOLYLMETHANE, 3,3'-di(indol-3-yl)methane, BML3-F11, CHEMBL446452, 3,3'-Diindolylmethane (DIM), DIINDOLYLMETHANE [VANDF], DTXSID8037047, GTPL11208, KBio2_000010, KBio2_002578, KBio2_005146, KBio3_000019, KBio3_000020, KBio3_003002, Bio1_000125, Bio1_000614, Bio1_001103, Bio2_000010, Bio2_000490, DIINDOLYLMETHANE, 3,3'-, HMS1361A12, HMS1791A12, HMS1989A12, HMS3402A12, 3,3'-diindolylmethane, AldrichCPR, ALBB-016048, BCP00470, CCG-39861, GR-207, HB 236, HSCI1_000069, s4728, STK263696, AKOS003627372, AM84671, CS-1652, DB11875, KS-5266, NSC-708486, SB16901, IDI1_033760, 3,3'-DIINDOLYLMETHANE [WHO-DD], NCGC00095348-01, NCGC00095348-02, NCGC00095348-03, NCGC00095348-04, NCGC00095348-05, NCGC00095348-06, NCGC00095348-07, 3-[(1H-indol-3-yl)methyl]-1H-indole, AC-11611, HY-15758, NCI60_038418, SMR001828114, SY038972, 3,3'-Diindolylmethane, >=98% (HPLC), 3,3'-Diindolylmethane, analytical standard, DB-011102, FT-0614061, M1399, NS00026401, A15023, D-3720, EN300-1717487, Q4634053, BRD-K37846922-001-05-2, BRD-K37846922-001-06-0, BRD-K37846922-001-09-4, Z56791159, 3,3'-Diindolylmethane;di(1H-indol-3-yl)methane ;3,3'-methylene-bisindole

No.	Title	Href
1	Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer. J Agric Food Chem. 2015 May 6;63(17):4297-304. doi: 10.1021/jf506098s.	`Click`

No.

Title

Href

Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer. J Agric Food Chem. 2015 May 6;63(17):4297-304. doi: 10.1021/jf506098s.

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Name	3,3'-diindolylmethane
PubChem CID	3071
Molecular Weight	246.31g/mol
Synonyms	3,3'-Diindolylmethane, 1968-05-4, diindolylmethane, di(1H-indol-3-yl)methane, 3,3'-Methylenebis-1H-indole, 3,3'-Methylenediindole, DIM, 1H-Indole, 3,3'-methylenebis-, 3-(1H-indol-3-ylmethyl)-1H-indole, ARUNDINE, 3,3-Diindolylmethane, 3,3'-Di-indolylmethane, Plant Indole, 3,3'-methylenebis(1H-indole), 33'-Diindolylmethane, Di(3-indolyl)methane, 3,3'-methanediylbis(1H-indole), MFCD00195766, SSZ9HQT61Z, bis-1H-indol-3-ylmethane, CHEBI:50182, 3,3,-diindolylmethane, 3,3 inverted exclamation marka-Diindolylmethane, 3-Diindolyl methane, 3,3'-Diindolymethane, Diidolylmethane, Infemin, CCRIS 5806, 33diindolylmethyle, Di-3-indolylmethane, NSC708486, 3-3-diindolylmethane, Bis (3-indolyl)methane, Spectrum2_001711, Spectrum3_001989, Spectrum5_001955, UNII-SSZ9HQT61Z, DIM;Arundine;HB 236, CBiol_001839, Oprea1_472633, Oprea1_740951, BSPBio_001290, BSPBio_003589, CBDivE_010856, KBioGR_000010, KBioSS_000010, MLS006011847, SCHEMBL325162, SPECTRUM1505331, SPBio_001722, 3-3'-DIINDOLYLMETHANE, 3,3'-di(indol-3-yl)methane, BML3-F11, CHEMBL446452, 3,3'-Diindolylmethane (DIM), DIINDOLYLMETHANE [VANDF], DTXSID8037047, GTPL11208, KBio2_000010, KBio2_002578, KBio2_005146, KBio3_000019, KBio3_000020, KBio3_003002, Bio1_000125, Bio1_000614, Bio1_001103, Bio2_000010, Bio2_000490, DIINDOLYLMETHANE, 3,3'-, HMS1361A12, HMS1791A12, HMS1989A12, HMS3402A12, 3,3'-diindolylmethane, AldrichCPR, ALBB-016048, BCP00470, CCG-39861, GR-207, HB 236, HSCI1_000069, s4728, STK263696, AKOS003627372, AM84671, CS-1652, DB11875, KS-5266, NSC-708486, SB16901, IDI1_033760, 3,3'-DIINDOLYLMETHANE [WHO-DD], NCGC00095348-01, NCGC00095348-02, NCGC00095348-03, NCGC00095348-04, NCGC00095348-05, NCGC00095348-06, NCGC00095348-07, 3-[(1H-indol-3-yl)methyl]-1H-indole, AC-11611, HY-15758, NCI60_038418, SMR001828114, SY038972, 3,3'-Diindolylmethane, >=98% (HPLC), 3,3'-Diindolylmethane, analytical standard, DB-011102, FT-0614061, M1399, NS00026401, A15023, D-3720, EN300-1717487, Q4634053, BRD-K37846922-001-05-2, BRD-K37846922-001-06-0, BRD-K37846922-001-09-4, Z56791159, 3,3'-Diindolylmethane;di(1H-indol-3-yl)methane ;3,3'-methylene-bisindole
Drug Type	Small molecule
Formula	C₁₇H₁₄N₂
SMILES	C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43
InChI	1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChIKey	VFTRKSBEFQDZKX-UHFFFAOYSA-N
CAS Number	1968-05-4
ChEMBL ID	CHEMBL446452
ChEBI ID	CHEBI:50182
Drug Bank ID	DB11875
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Capsaicin, 3,3'-diindolylmethane
Partner Name	Capsaicin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAK1	hsa578
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	BBC3	hsa27113
	Up-regulation	Expression	BID	hsa637
	Up-regulation	Expression	CDH13	hsa1012
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	CDK6	hsa1021
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	FAS	hsa355
	Up-regulation	Expression	IFI27	hsa3429
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	LoVo	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0399
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
	Caco-2	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0025
	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
Result	The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-κB, p53, and target genes associated with apoptosis.