Gallate, Propyl, Propyl Gallate
| Name | Propyl gallate | ||
| PubChem CID | 4947 | ||
| Molecular Weight | 212.20g/mol | ||
| Synonyms |
Gallate, Propyl, Propyl Gallate |
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| Formula | C₁₀H₁₂O₅ | ||
| SMILES | CCCOC(=O)C1=CC(=C(C(=C1)O)O)O | ||
| InChI | 1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3 | ||
| InChIKey | ZTHYODDOHIVTJV-UHFFFAOYSA-N | ||
| CAS Number | 121-79-9 | ||
| ChEMBL ID | CHEMBL7983 | ||
| ChEBI ID | CHEBI:10607 | ||
| Drug Bank ID | DB12450 | ||
| KEGG ID | C11155 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ChiShao | ||
| Use Part | Root | ||
| Habitat | Shaanxi, GanSu, QingHai, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Saxifragales
-->Family: Paeoniaceae
-->Genus: Paeonia
-->Species: Paeonia veitchii
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| Chineses Pinyin | ShaoYao | ||
| Use Part | Root | ||
| Habitat | ZheJiang, AnHui, SiChuan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Saxifragales
-->Family: Paeoniaceae
-->Genus: Paeonia
-->Species: Paeonia lactiflora
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| Pair Name | Propyl gallate, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Target-->HO-1 | |||
| Gene Regulation | Down-regulation | Expression | HMOX1 | hsa3162 |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | RNF139 | hsa11236 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | Our data provide the potential application of PG in combination chemotherapy to enhance drug sensitivity in lung cancer by targeting HO-1. | |||
| Pair Name | Propyl gallate, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Inhibition-->ROS generation | |||
| Gene Regulation | Down-regulation | Activity | MMP9 | hsa4318 |
| Down-regulation | Activity | MMP2 | hsa4313 | |
| Down-regulation | Phosphorylation | CHUK | hsa1147 | |
| Down-regulation | Phosphorylation | IKBKE | hsa9641 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| Result | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation. Eur J Pharmacol. 2016 Oct 5;788:321-327. doi: 10.1016/j.ejphar.2016.06.052. | Click |
| 2 | Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-κB Pathway. J Immunol Res. 2017;2017:9489383. doi: 10.1155/2017/9489383. | Click |
