| Pair Name | Oxyresveratrol, Dacarbazine | ||
| Phytochemical Name | Oxyresveratrol (PubChem CID: 5281717 ) | ||
| Anticancer drug Name | Dacarbazine (PubChem CID: 135398738 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Oxyresveratrol, Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in S phase | |||
| Gene Regulation | Down-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | NOTCH2 | hsa4853 | |
| Down-regulation | Expression | NOTCH3 | hsa4854 | |
| In Vitro Model | WM266-4 | Melanoma | Homo sapiens (Human) | CVCL_2765 |
| Result | This combination treatment may serve as a novel therapeutic strategy for treating malignant melanoma. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic inhibitory effects of the oxyresveratrol and dacarbazine combination against melanoma cells. Oncol Lett. 2021 Sep;22(3):667. doi: 10.3892/ol.2021.12928. | Click |
