| Pair Name | Oleanolic Acid, Doxorubicin | ||
| Phytochemical Name | Oleanolic Acid (PubChem CID: 10494 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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| Drug Name | Doxorubicin |
| Adverse Reactions | Nausea, vomiting, diarrhoea. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Ligusticum chuam; Angelica sinensis; Zingiber officinale; Panax ginseng; Pogostemon cablin |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Oleanolic Acid, Doxorubicin | |||
| Disease Info | [ICD-11: 2C10.Z] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | DIABLO | hsa56616 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP8 | hsa841 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 |
| MRC-5 | Healthy | Homo sapiens (Human) | CVCL_0440 | |
| Result | This approach may increase the efficiency of chemotherapy and reduce unintended side effects by lowering the prescribed dose of DOX. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Oleanolic acid increases the anticancer potency of doxorubicin in pancreatic cancer cells. J Biochem Mol Toxicol. 2023 Oct;37(10):e23426. doi: 10.1002/jbt.23426. | Click |
