narirutin
| Name | Narirutin | ||
| PubChem CID | 442431 | ||
| Molecular Weight | 580.5g/mol | ||
| Synonyms |
narirutin |
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| Formula | C₂₇H₃₂O₁₄ | ||
| SMILES | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)O)O)O)O)O)O | ||
| InChI | 1S/C27H32O14/c1-10-20(31)22(33)24(35)26(38-10)37-9-18-21(32)23(34)25(36)27(41-18)39-13-6-14(29)19-15(30)8-16(40-17(19)7-13)11-2-4-12(28)5-3-11/h2-7,10,16,18,20-29,31-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26+,27+/m0/s1 | ||
| InChIKey | HXTFHSYLYXVTHC-AJHDJQPGSA-N | ||
| CAS Number | 14259-46-2 | ||
| ChEMBL ID | CHEMBL446246 | ||
| ChEBI ID | CHEBI:28705 | ||
| Herb ID | HBIN036381 | ||
| KEGG ID | C09793 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ChenPi | ||
| Use Part | Pericarp | ||
| Habitat | FuJian, TaiWan, GuangDong, GuangXi | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Lung, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Citrus
-->Species: Citrus reticulata
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| Chineses Pinyin | GanJu | ||
| Use Part | Fruit; Peel; Juice | ||
| Habitat | JiangSu, ZheJiang, AnHui, JiangXi, HuBei, HuNan, GuangDong, GuangXi, HaiNan, SiChuan, GuiZhou, YunNan, TaiWan | ||
| Flavor | Sour | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Rutaceae
-->Genus: Citrus
-->Species: Citrus reticulata
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| Pair Name | Narirutin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Ion channel protein | |||
| Gene Regulation | Down-regulation | Expression | ANO1 | hsa55107 |
| Down-regulation | Phosphorylation | MAP2K7 | hsa5609 | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Expression | CDH2 | hsa1000 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | LA-795 | Adenocarcinoma of the mouse pulmonary system | Mus musculus (Mouse) | CVCL_G363 |
| In Vivo Model | LA795 cells were inoculated to Balb/c mice (6- to 8-week-old) in the right forelimb. Tumor volumes were measured every 5 day. | |||
| Result | Based on the significant anticancer effect and high biosafety, naringin has great potential as a functional food in the adjuvant treatment of lung cancer. | |||
