Pair Name | Narciclasine, Tamoxifen | ||
Phytochemical Name | Narciclasine (PubChem CID: 72376 ) | ||
Anticancer drug Name | Tamoxifen (PubChem CID: 2733526 ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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Pair Name | Narciclasine, Tamoxifen | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Biological Phenomena | Target-->STAT3 | |||
Gene Regulation | Down-regulation | Expression | BIRC5 | hsa332 |
Down-regulation | Expression | CCND1 | hsa595 | |
Down-regulation | Expression | MYC | hsa4609 | |
Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
Up-regulation | Expression | TP53 | hsa7157 | |
In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
Result | Our findings successfully highlight the STAT3 as the direct therapeutic target of Nar in ER-positive breast cancer cells, especially, Nar leaded STAT3 degradation as a promising strategy for the tamoxifen-resistant breast cancer treatment. |
No. | Title | Href |
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1 | Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Mol Ther Oncolytics. 2022 Jan 3;24:340-354. doi: 10.1016/j.omto.2021.12.025. | Click |