| Name | Urokinase-type plasminogen activator | ||
| UniProt ID | UROK_HUMAN | ||
| Gene Name | PLAU | ||
| Gene ID | 5328 | ||
| Synonyms |
PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA
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| Sequence |
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR SHTKEENGLAL |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 2.A.3.8.25; 2.A.6.7.8; 2.A.68.1.2; 3.A.1.211.14; 8.A.31.1.2 | ||
| KEGG ID | hsa5328 | ||
| TTD ID | T17758 | ||
| Pfam | PF00051; PF00089; PF03761; PF09342 | ||
| Pair Name | Licochalcone A, Sorafenib | |||
| Phytochemical | Licochalcone A | |||
| Drug | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Urokinase-type plasminogen activator | Expression | |
| Result | These findings first revealed the synergistic effects of LicA and Sor cotreatment against human HCC cells, further suggesting that beneficial effects on tumor regression could be confirmed through prospective clinical trials. | |||
| Pair Name | Matairesinol, Fluorouracil | |||
| Phytochemical | Matairesinol | |||
| Drug | Fluorouracil | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Regulate Info | Down-regulation | Urokinase-type plasminogen activator | Expression | |
| Result | Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells | |||
| Pair Name | Ursolic acid, Doxorubicin | |||
| Phytochemical | Ursolic acid | |||
| Drug | Doxorubicin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Regulate Info | Down-regulation | Urokinase-type plasminogen activator | Expression | |
| Result | UA may be a novel anticancer strategy and could be considered for investigation as a complementary chemotherapy agent in the future. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630. | Click |
| 2 | Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells. Mar Drugs. 2022 Jul 25;20(8):473. doi: 10.3390/md20080473. | Click |
| 3 | Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling pathway. Mol Med Rep. 2023 Jan;27(1):11. doi: 10.3892/mmr.2022.12898. | Click |
