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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Kaempferol, Cisplatin
Phytochemical Name Kaempferol (PubChem CID: 5280863 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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2D MOL 3D MOL
Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 631
Ref_1
Pair Name Kaempferol, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress and autophagy
Gene Regulation Up-regulation Expression CDKN1A hsa1026
Down-regulation Expression MYC hsa4609
In Vitro Model OVCAR-3 High grade ovarian serous adenocarcinoma Homo sapiens (Human) CVCL_0465
Result Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc
Combination Pair ID: 630
Ref_2
Pair Name Kaempferol, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Biological Phenomena Induction-->Endoplasmic reticulum stress and autophagy
Gene Regulation Down-regulation Expression AKT1 hsa207
Up-regulation Expression ATF6 hsa22926
Up-regulation Expression BECN1 hsa8678
Up-regulation Expression CASP4 hsa837
Up-regulation Expression EIF2AK3 hsa9451
Up-regulation Expression HSPA5 hsa3309
Up-regulation Expression MAP1LC3A hsa84557
In Vitro Model A2780 Ovarian endometrioid adenocarcinoma Homo sapiens (Human) CVCL_0134
Result Kaempferol Induces cell death in A2780 ovarian cancer cells and increases their sensitivity to cisplatin by activation of cytotoxic endoplasmic reticulum-mediated autophagy and inhibition of protein kinase B
Reversing Drug Resistance
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Combination Pair ID: 629
Ref_3
Pair Name Kaempferol, Cisplatin
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Cleavage PARP1 hsa142
Down-regulation Phosphorylation POLD1 hsa5424
Down-regulation Phosphorylation RB1 hsa5925
In Vitro Model LS174T Colon adenocarcinoma Homo sapiens (Human) CVCL_1384
Result Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
03. Reference
No. Title Href
1 Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int. 2010 May 11;10:16. doi: 10.1186/1475-2867-10-16. Click
2 Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B. Folia Biol (Praha). 2020;66(1):36-46. Click
3 The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells. Sci Rep. 2019 Jan 17;9(1):195. doi: 10.1038/s41598-018-36808-z. Click
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