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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Hispidin, Gemcitabine
Phytochemical Name Hispidin (PubChem CID: 54685921 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 496
Ref_1
Pair Name Hispidin, Gemcitabine
Disease Info [ICD-11: 2C10.Z] Pancreatic cancer Investigative
Gene Regulation Down-regulation Expression NFKB1 hsa4790
Down-regulation Expression TP53 hsa7157
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage PARP1 hsa142
Down-regulation Expression CD44 hsa960
Down-regulation Expression NANOG hsa79923
Down-regulation Expression SOX2 hsa6657
In Vitro Model BxPC-3 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0186
AsPC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0152
Result Hispidin might be a novel chemosensitizer for gemcitabine and a potential synergistic agent for increasing the therapeutic index of gemcitabine as a treatment for pancreatic cancer.
03. Reference
No. Title Href
1 Combination Effects of Hispidin and Gemcitabine via Inhibition of Stemness in Pancreatic Cancer Stem Cells. Anticancer Res. 2018 Jul;38(7):3967-3975. doi: 10.21873/anticanres.12683. Click
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