Pair Name	Cryptotanshinone, Trifluridine
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Phosphorylation	STAT3	hsa6774
	Up-regulation	Expression	CCNB1	hsa891
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP9	hsa842
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	JAK2	hsa3717
In Vitro Model	HGC-27	Gastric carcinoma	Homo sapiens (Human)	CVCL_1279
	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
In Vivo Model	After adaptive feeding for 1 week, 100 µl cell suspension of HGC-27 cells was injected into the axilla of the nude mice with a density of 4×10⁷ cells/ml.
Result	FTD combined with CTS has a synergistic anti-gastric cancer effect as shown by in vitro and in vivo experiments, and the combined treatment of FTD and CTS will be a promising treatment option for advanced gastric cancer.