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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Berberine, Cisplatin
Phytochemical Name Berberine (PubChem CID: 2353 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 602
Ref_1
Pair Name Berberine, Cisplatin
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CDK4 hsa1019
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Phosphorylation MAPK14 hsa1432
Down-regulation Phosphorylation MAPK8 hsa5599
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
In Vitro Model MG-63 Osteosarcoma Homo sapiens (Human) CVCL_0426
Result Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway
03. Reference
No. Title Href
1 Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway. Molecules. 2021 Mar 17;26(6):1666. doi: 10.3390/molecules26061666. Click
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