| Pair Name | Astaxanthin, Cytarabine | ||
| Phytochemical Name | Astaxanthin (PubChem CID: 5281224 ) | ||
| Anticancer drug Name | Cytarabine (PubChem CID: 6253 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Astaxanthin, Cytarabine | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Up-regulation | Expression | CASP8 | hsa841 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Down-regulation | Expression | BCL-xL | hsa598 | |
| Down-regulation | Expression | IL6 | hsa3569 | |
| Down-regulation | Expression | TNF | hsa7124 | |
| In Vitro Model | NALM-6 | Adult B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0092 |
| Result | Co-treatment of ASX and Ara-C has synergism effects on apoptosis pathways, cell proliferation inhibition, and decreased inflammation. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Astaxanthin decreases the growth-inhibitory dose of cytarabine and inflammatory response in the acute lymphoblastic leukemia cell line NALM-6. Mol Biol Rep. 2022 Jul;49(7):6415-6422. doi: 10.1007/s11033-022-07452-8. | Click |
