Name | lambda-Carrageenan Oligosaccharides | ||
PubChem CID | / | ||
Structure |
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2D
MOL
3D
MOL
|
Chineses Pinyin | HongZao |
Pair Name | lambda-Carrageenan Oligosaccharides, Fluorouracil | |||
Partner Name | Fluorouracil | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Biological Phenomena | Induction-->Immunomodulatory | |||
Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
Down-regulation | Expression | BCL2 | hsa596 | |
Up-regulation | Cleavage | CASP8 | hsa841 | |
Up-regulation | Expression | IFNG | hsa3458 | |
Up-regulation | Expression | PAWR | hsa5074 | |
Down-regulation | Expression | RELA | hsa5970 | |
Up-regulation | Expression | TNF | hsa7124 | |
In Vitro Model | BGC-823 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3360 |
THP-1 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0006 | |
In Vivo Model | To generate the xenograft animal models, about 2×10⁷ BGC-823 cells in 100 μL PBS were subcutaneously injected into the left front axilla of BALB/c mice. | |||
Result | These findings suggested that λ-COS could be used as an immune-modulating agent for chemotherapy. |