| Pair Name | Withaferin A, Fluorouracil | ||
| Phytochemical Name | Withaferin A (PubChem CID: 265237 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Withaferin A, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Down-regulation | Expression | CTNNB1 | hsa1499 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Expression | EIF2AK3 | hsa9451 | |
| Up-regulation | Expression | EIF2S1 | hsa1965 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| In Vitro Model | SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| Result | Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells. Am J Cancer Res. 2020 Mar 1;10(3):799-815. | Click |
