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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sulforaphene, Cisplatin
Phytochemical Name Sulforaphene (PubChem CID: 6433206 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 574
Ref_1
Pair Name Sulforaphene, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian Cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP8 hsa841
Up-regulation Expression CASP9 hsa842
Up-regulation Expression CYCS hsa54205
Down-regulation Expression PIK3CA hsa5290
Up-regulation Activity PTEN hsa5728
In Vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0532
SNU-8 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_5096
Result SFE synergistically inhibited proliferation and induced apoptosis of SKOV3 and SNU8 cells in combination with cisplatin by activating multiple apoptotic pathways. Therefore, we suggest sulforaphene as a chemo-enhancing adjuvant to improve the efficacy of cisplatin in ovarian cancer treatment.
03. Reference
No. Title Href
1 Sulforaphene Synergistically Sensitizes Cisplatin via Enhanced Mitochondrial Dysfunction and PI3K/PTEN Modulation in Ovarian Cancer Cells. Anticancer Res. 2015 Jul;35(7):3901-8. Click
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