TOP
Nav Bar
  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sulforaphene, Cisplatin
Phytochemical Name Sulforaphene (PubChem CID: 6433206 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
Download
2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
Download
2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
Hide/Show
Enhancing Drug Efficacy
Hide/Show
Combination Pair ID: 574
Ref_1
Pair Name Sulforaphene, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian Cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP9 hsa842
Up-regulation Expression CYCS hsa54205
Up-regulation Expression CASP8 hsa841
Down-regulation Expression PIK3CA hsa5290
Up-regulation Activity PTEN hsa5728
In Vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0532
SNU-8 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_5096
Result SFE synergistically inhibited proliferation and induced apoptosis of SKOV3 and SNU8 cells in combination with cisplatin by activating multiple apoptotic pathways. Therefore, we suggest sulforaphene as a chemo-enhancing adjuvant to improve the efficacy of cisplatin in ovarian cancer treatment.
03. Reference
No. Title Href
1 Sulforaphene Synergistically Sensitizes Cisplatin via Enhanced Mitochondrial Dysfunction and PI3K/PTEN Modulation in Ovarian Cancer Cells. Anticancer Res. 2015 Jul;35(7):3901-8. Click
It has been 426014 visits since 2024.08
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang
TOP