| Pair Name | Oleandrin, Cisplatin | ||
| Phytochemical Name | Oleandrin (PubChem CID: 11541511 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
3D
MOL
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| Pair Name | Oleandrin, Cisplatin | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Activity | MAPK14 | hsa1432 | |
| Up-regulation | Activity | ELK1 | hsa2002 | |
| In Vitro Model | 143B | Osteosarcoma | Homo sapiens (Human) | CVCL_2270 |
| U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 | |
| MG-63 | Osteosarcoma | Homo sapiens (Human) | CVCL_0426 | |
| Result | The combination of oleandrin with cisplatin exerts a synergistic antitumor effect in osteosarcoma, which relates to the activation of the p38 MAPK pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Oleandrin synergizes with cisplatin in human osteosarcoma cells by enhancing cell apoptosis through activation of the p38 MAPK signaling pathway. Cancer Chemother Pharmacol. 2018 Dec;82(6):1009-1020. doi: 10.1007/s00280-018-3692-7. | Click |
