Pair Name	Gynostemma Extract, Fluorouracil
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Phosphorylation	TP53	hsa7157
	Up-regulation	Expression	ROS1	hsa6098
	Up-regulation	Phosphorylation	H2AX	hsa3014
In Vitro Model	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
	SW620	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0547
	Caco-2	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0025
In Vivo Model	Three mice were used as normal control, all others were inoculated with 0.1 ml of CT-26 cells (1×10⁷ cells/ml) into the left oxter region and randomly divided into 6 groups with 6–8 animals in each group.
Result	Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation