Pair Name	Britannin, Vincristine
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Biological Phenomena	Induction-->ROS-mediated apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BIM	hsa10018
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	PSMD9	hsa5715
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	MOLT-4	Adult T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0013
Result	The results of this study showed for the first time that Britannin, as a natural Sesquiterpene Lactone, has cytotoxic effects that could be considered as an anti-leukemic agent in the treatment of ALL. However, there is still a demand for further studies that examine the efficacy and the safety of this purified compound.

Pair Name	Britannin, Vincristine
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Biological Phenomena	Induction-->ROS-mediated apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	PSMD9	hsa5715
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	NALM-6	Adult B acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0092
	Reh	Childhood B acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_1650
	Jurkat	Childhood T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0065
Result	Our results proposed a mechanism for the cytotoxic effect of Britannin, either as a single agent or in combination with Vincristine, in NALM-6 cells.