britannin
| Name | Britannin | ||
| PubChem CID | 14466541 | ||
| Molecular Weight | 366.4g/mol | ||
| Synonyms |
britannin |
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| Formula | C₁₉H₂₆O₇ | ||
| SMILES | CC1CC2C(C(C3(C1C(CC3O)OC(=O)C)C)OC(=O)C)C(=C)C(=O)O2 | ||
| InChI | 1S/C19H26O7/c1-8-6-12-15(9(2)18(23)26-12)17(25-11(4)21)19(5)14(22)7-13(16(8)19)24-10(3)20/h8,12-17,22H,2,6-7H2,1,3-5H3/t8-,12+,13+,14+,15-,16-,17+,19-/m1/s1 | ||
| InChIKey | JXEGMONJOSAULB-IZZBGLMFSA-N | ||
| ChEMBL ID | CHEMBL1165708 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | PaiQianShu | ||
| Use Part | Root and Leaf | ||
| Flavor | Astringent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Phyllodium
-->Species: Phyllodium pulchellum
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| Pair Name | Britannin, Vincristine | |||
| Partner Name | Vincristine | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->ROS-mediated apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | NALM-6 | Adult B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0092 |
| Reh | Childhood B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_1650 | |
| Jurkat | Childhood T acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0065 | |
| Result | Our results proposed a mechanism for the cytotoxic effect of Britannin, either as a single agent or in combination with Vincristine, in NALM-6 cells. | |||
| Pair Name | Britannin, Vincristine | |||
| Partner Name | Vincristine | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->ROS-mediated apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | BIM | hsa10018 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | MOLT-4 | Adult T acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0013 |
| Result | The results of this study showed for the first time that Britannin, as a natural Sesquiterpene Lactone, has cytotoxic effects that could be considered as an anti-leukemic agent in the treatment of ALL. However, there is still a demand for further studies that examine the efficacy and the safety of this purified compound. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Britannin, a sesquiterpene lactone induces ROS-dependent apoptosis in NALM-6, REH, and JURKAT cell lines and produces a synergistic effect with vincristine. Mol Biol Rep. 2021 Sep;48(9):6249-6258. doi: 10.1007/s11033-021-06572-x. | Click |
| 2 | Britannin a Sesquiterpene Lactone from Inula aucheriana Exerted an Anti-leukemic Effect in Acute Lymphoblastic Leukemia (ALL) Cells and Enhanced the Sensitivity of the Cells to Vincristine. Nutr Cancer. 2022;74(3):965-977. doi: 10.1080/01635581.2021.1931700. | Click |
