| Pair Name | Artesunate, Venetoclax | ||
| Phytochemical Name | Artesunate (PubChem CID: 6917864 ) | ||
| Anticancer drug Name | Venetoclax (PubChem CID: 49846579 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
3D
MOL
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| Pair Name | Artesunate, Venetoclax | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Down-regulation | Expression | PMAIP1 | hsa5366 |
| Down-regulation | Expression | MCL1 | hsa4170 | |
| Up-regulation | Expression | BCL2L11 | KEGG ID N.A. | |
| Down-regulation | Phosphorylation | CHEK1 | hsa1111 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | THP-1 | Childhood acute monocytic leukemia | Homo sapiens (Human) | CVCL_0006 |
| MOLM-13 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_2119 | |
| In Vivo Model | NOD/SCID mice (8 weeks) were injected with 5×10⁶ log-phase MOLM-13 cells subcutaneously in the right flank. | |||
| Result | We provide a new triple combination for AML treatment by targeting the Noxa/Mcl-1/Bim axis to reverse Mcl-1/p-Chk1 resistance of cytarabine therapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis. Cell Death Dis. 2022 Apr 20;13(4):379. doi: 10.1038/s41419-022-04810-z. | Click |
