Pair Name	Xanthohumol, Praziquantel
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Phosphorylation	MAPK14	hsa1432
	Down-regulation	Expression	TFRC	hsa7037
In Vivo Model	Six- to eight-week-old male Syrian golden hamsters were randomly divided into four groups as followings: group I, Ov infection and NDMA administration (ON); group II, Ov infection and NDMA administration and PZ treatment (ONP); groups III and IV were similar to group I and II, they received 20 μM XN (171 mg/B.W./day) designated as XON and XONP groups, respectively.
Result	XN administered in combination with PZ could efficiently prevent CCA development and hence provide potential chemopreventive benefits in Ov-induced cholangiocarcinogenesis