| Name | Transferrin receptor protein 1 | ||
| UniProt ID | TFR1_HUMAN | ||
| Gene Name | TFRC | ||
| Gene ID | 7037 | ||
| Synonyms |
TFRC, CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90
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| Sequence |
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK
RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 9.B.229.1.1 | ||
| KEGG ID | hsa7037 | ||
| TTD ID | T33976 | ||
| Pfam | PF02225; PF04253; PF04389; PF12967 | ||
| Pair Name | Baicalin, Fluorouracil | |||
| Phytochemical | Baicalin | |||
| Drug | Fluorouracil | |||
| Disease Info | [ICD-11: 2B72.Z] | Gastric cancer | Investigative | |
| Regulate Info | Up-regulation | Transferrin receptor protein 1 | Expression | |
| Result | Baicalin inhibits GC and enhances 5-Fu by promoting ROS-related ferroptosis in GC. | |||
| Pair Name | Xanthohumol, Praziquantel | |||
| Phytochemical | Xanthohumol | |||
| Drug | Praziquantel | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Regulate Info | Down-regulation | Transferrin receptor protein 1 | Expression | |
| Result | XN administered in combination with PZ could efficiently prevent CCA development and hence provide potential chemopreventive benefits in Ov-induced cholangiocarcinogenesis | |||
| No. | Title | Href |
|---|---|---|
| 1 | Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis. Biomed Pharmacother. 2023 Aug;164:114986. doi: 10.1016/j.biopha.2023.114986. | Click |
| 2 | Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis. PeerJ. 2018 Jan 22;6:e4281. doi: 10.7717/peerj.4281. | Click |
