Pair Name	Tiliroside, Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Down-regulation	Expression	FTH1	hsa2495
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	GPX4	hsa2879
	Down-regulation	Expression	G6PD	hsa2539
	Up-regulation	Expression	KEAP1	hsa9817
	Up-regulation	Expression	SQSTM1	hsa8878
	Down-regulation	Phosphorylation	TBK1	hsa29110
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
In Vivo Model	A total of 2.5×10⁶ HepG2-luciferase cells/100 µl were injected into the left axilla of mice.
Result	Our findings imply that tiliroside is a potent TBK1 inhibitor and a candidate natural anti-cancer product that could function as a sensitizer of sorafenib in HCC treatment by targeting TBK1 to induce ferroptosis.