Pair Name	Dihydroartemisinin, Cisplatin
Phytochemical Name	Dihydroartemisinin
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Ferritin heavy chain		Expression
Result	DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism

Pair Name	All-trans retinoic acid, Decitabine
Phytochemical	All-trans-retinoic acid
Drug	Decitabine
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Ferritin heavy chain		Expression
Result	These results demonstrate that combining DAC and ATRA has potential for the clinical treatment of HR-MDS/AML and merits further exploration.

Pair Name	Beta-Elemene, Cetuximab
Phytochemical	Beta-Elemene
Drug	Cetuximab
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Ferritin heavy chain		Expression
Result	natural product β-elemene is a new ferroptosis inducer and combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant CRC cells by inducing ferroptosis and inhibiting EMT, which will hopefully provide a prospective strategy for CRC patients with RAS mutations.

Pair Name	Tiliroside, Sorafenib
Phytochemical	Tiliroside
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Ferritin heavy chain		Expression
Result	Our findings imply that tiliroside is a potent TBK1 inhibitor and a candidate natural anti-cancer product that could function as a sensitizer of sorafenib in HCC treatment by targeting TBK1 to induce ferroptosis.