| Pair Name | Scutellarin, Oxaliplatin | ||
| Phytochemical Name | Scutellarin (PubChem CID: 185617 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Scutellarin, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Mitochondria-mediated apoptosis | |||
| Gene Regulation | Down-regulation | Activity | PKM | hsa5315 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 |
| HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 | |
| Result | It was indicated that scutellarin resensitizes oxaliplatin-resistant CRC cells to oxaliplatin treatment through inhibition of PKM2. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Scutellarin resensitizes oxaliplatin-resistant colorectal cancer cells to oxaliplatin treatment through inhibition of PKM2. Mol Ther Oncolytics. 2021 Mar 17;21:87-97. doi: 10.1016/j.omto.2021.03.010. | Click |
