Pair Name	Rutaecarpine, Fluorouracil
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
	SW480	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0546
	RKO	Colon carcinoma	Homo sapiens (Human)	CVCL_0504
In Vivo Model	Each mouse was subcutaneously injected with 1×10⁶ of an HCT cell suspension near the right axilla and the tumor size and weight of each mouse were measured every other day.
Result	Combined therapy with 5-FU and RUT exerted a superior curative effect in CRC than treatment with either single drug alone and has potential as a novel therapeutic modality for the treatment of CRC.